Frizzled 4/CD344 Antibody (YA7110)
(Synonyms: CD344, Frizzled-4, Fz-4, hFz4, FzE4, FZD4)Frizzled 4/CD344 Antibody (YA7110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 4/CD344.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
Frizzled 4/CD344 Antibody (YA7110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 4/CD344.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 60kDa;
SwissProt: SwissProt: Q9ULV1
Purified recombinant fragment of human CD344 (AA: extra 37-222) expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Frizzled 4/CD344 receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues[1].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Almost ubiquitous (PubMed:10544037). Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney (PubMed:10544037). Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver (PubMed:10544037) -
Isoforms & Post-Translational Modification
Q9ULV1: 537 amino acids, molecular weight 59881 Da.
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Subunit
Interacts with MAGI3 and NDP (By similarity)
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SwissProt ID
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Synonyms
CD344, Frizzled-4, Fz-4, hFz4, FzE4, FZD4
Documentation
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