2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Flow Cytometry Antibodies
  5. Frizzled 4/CD344 Antibody (YA7110)

Frizzled 4/CD344 Antibody (YA7110)

製品番号: HY-P87422
User Guide for Antibodies Technical Support

Frizzled 4/CD344 Antibody (YA7110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 4/CD344.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Frizzled 4/CD344 Antibody (YA7110) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Frizzled 4/CD344.
Host

Mouse
Clonality

Monoclonal
分子量

Predicted band size: 60kDa;
Species Reactivity
Human
SwissProt ID
Immunogen

Purified recombinant fragment of human CD344 (AA: extra 37-222) expressed in E. Coli.
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
1:200-1:400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous 純度 affinity purified.
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Solution
Formulation

Supplied in PBS with 0.05% sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
Subcellular Localization：Cell membrane
Expression：
Tissue_Specificity: Almost ubiquitous (PubMed:10544037). Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney (PubMed:10544037). Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver (PubMed:10544037)
Isoforms & Post-Translational Modification：Q9ULV1: 537 amino acids, molecular weight 59881 Da.
Subunit：Interacts with MAGI3 and NDP (By similarity)
Database

SwissProt: SwissProt: Q9ULV1

Synonyms
CD344, Frizzled-4, Fz-4, hFz4, FzE4, FZD4
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Frizzled 4/CD344 Antibody (YA7110) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Frizzled 4/CD344 Antibody (YA7110)
製品番号:
HY-P87422
数量:
MCE 日本正規代理店:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

国或いは地域 *

メールアドレス *

     

電話番号 *

 

組纖名 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.