FXYD3 Antibody (YA7829)
(Synonyms: MAT8; PLML)FXYD3 Antibody (YA7829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to FXYD3.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
FXYD3 Antibody (YA7829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to FXYD3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 7.1 kDa
Full length human recombinant protein of human FXYD3 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FXYD3 associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes |Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials|Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials[1][2][3].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level) -
Isoforms & Post-Translational Modification
Q14802 has 5 isomers: Q14802-1: 9263 Da (predicted); Q14802-2: 11988 Da (predicted); Q14802-3: 15154 Da (predicted); Q14802-4: 10280 Da (predicted); Q14802-5: 6718 Da (predicted).
Glutathionylated -
Subunit
Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:17077088)
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SwissProt ID
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Synonyms
MAT8; PLML
Documentation
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