Glucose 6 Phosphate Dehydrogenase Antibody (YA4869)
(Synonyms: G6PD; Glucose-6-phosphate 1-dehydrogenase; G6PD)Glucose 6 Phosphate Dehydrogenase Antibody (YA4869) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 | 1:50-200 |
Product Details
Glucose 6 Phosphate Dehydrogenase Antibody (YA4869) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 59 kDa;
Purified recombinant fragment of human G6PD expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Glucose 6 Phosphate Dehydrogenase catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis
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Subcellular Localization
Cytoplasm, cytosol; Membrane; Peripheral membrane protein
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Expression
Tissue_specificity:The long subtype is found in lymphoblasts, granulocytes, and sperm. -
Isoforms & Post-Translational Modification
P11413 has 3 isomers: P11413-1: 59257 Da (predicted); P11413-2: 63827 Da (predicted); P11413-3: 62468 Da (predicted).
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity -
Subunit
Homotetramer; dimer of dimers (PubMed:10745013, PubMed:15858258, PubMed:24769394, PubMed:38066190). Interacts with SIRT2; the interaction is enhanced by H(2)O(2) treatment (PubMed:24769394). Forms a ternary complex with ALDOB and TP53; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check
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SwissProt ID
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Synonyms
G6PD; Glucose-6-phosphate 1-dehydrogenase; G6PD
Documentation
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