G9P/CD158D Antibody (YA7099)

Cat. No.: HY-P87411: Data Sheet User Guide for Antibodies
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G9P/CD158D Antibody (YA7099) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to G9P/CD158D.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

G9P/CD158D Antibody (YA7099) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to G9P/CD158D.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 41.5kDa;

Species Reactivity

Human

SwissProt ID

Q99706

Immunogen

Purified recombinant fragment of human CD158D (AA: extra 22-120) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	Purity	affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272)

Subcellular Localization：Cell membrane,Early endosome membrane

Expression：
Tissue_Specificity: Expressed in decidual NK cells and innate lymphoid cell type I (ILC1) (PubMed:29262349). Expressed in a subset of peripheral NK cells (PubMed:19304799)

Isoforms & Post-Translational Modification：Q99706 has 6 isomers: Q99706-1: 41487 Da (predicted); Q99706-2: 39699 Da (predicted); Q99706-3: 37356 Da (predicted); Q99706-4: 35568 Da (predicted); Q99706-5: 33591 Da (predicted); Q99706-6: 24917 Da (predicted).

Subunit：Interacts with peptide-bound HLA-G-B2M heterotrimeric complex (PubMed:10190900, PubMed:16366734)

Database

SwissProt: SwissProt: Q99706

Documentation

User Guide for Antibodies (1077 KB)