GAB2 Antibody (YA7091)(PBS only)
(Synonyms: KIAA0571, GAB2, GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100)GAB2 Antibody (YA7091) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GAB2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
GAB2 Antibody (YA7091) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GAB2.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 74.5kDa;
Purified recombinant fragment of human GAB2 (AA: 332-476) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2a
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GAB2 is an Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis
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Subcellular Localization
Cytoplasm,Cell membrane,Membrane raft
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Isoforms & Post-Translational Modification
Q9UQC2 has two isomers: Q9UQC2-1: 74458 Da (predicted); Q9UQC2-2: 69968 Da (predicted).
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity)丨Dephosphorylated by PTPN11 -
Subunit
Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294)
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SwissProt ID
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Synonyms
KIAA0571, GAB2, GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100
Documentation
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