GAB2 Antibody (YA7091)

Cat. No.: HY-P87403: Data Sheet User Guide for Antibodies
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GAB2 Antibody (YA7091) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GAB2.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GAB2 Antibody (YA7091) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GAB2.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 74.5kDa;

Species Reactivity

Human

SwissProt ID

Q9UQC2

Immunogen

Purified recombinant fragment of human GAB2 (AA: 332-476) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	Purity	affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis

Subcellular Localization：Cytoplasm,Cell membrane,Membrane raft

Isoforms & Post-Translational Modification：Q9UQC2 has two isomers: Q9UQC2-1: 74458 Da (predicted); Q9UQC2-2: 69968 Da (predicted).
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity)丨Dephosphorylated by PTPN11

Subunit：Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294)

Database

SwissProt: SwissProt: Q9UQC2

Documentation

User Guide for Antibodies (1077 KB)