GBP2 Antibody (YA8423)(PBS only)

Cat. No.: HY-P88739A: Data Sheet User Guide for Antibodies
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GBP2 Antibody (YA8423) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GBP2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GBP2 Antibody (YA8423) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GBP2.

Host

Mouse

Molecular Weight

Predicted band size: 67 kDa

Species Reactivity

Human

SwissProt ID

P32456

Immunogen

Full length human recombinant protein of human GBP2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-250
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448)

Subcellular Localization：Cytoplasmic vesicle membrane,Golgi apparatus membrane,Cytoplasm,Cytoplasm, perinuclear region

Expression：Induction: By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B

Isoforms & Post-Translational Modification：P32456: 591 amino acids, molecular weight 67209 Da.

Subunit：Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures (PubMed:21151871)

Synonyms

DKFZp451C2311

Documentation

User Guide for Antibodies (1077 KB)