GBP2 Antibody (YA8423)(PBS only)
(Synonyms: DKFZp451C2311)GBP2 Antibody (YA8423) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GBP2.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:50-250 | 1:100-250 | 1:100 |
Product Details
GBP2 Antibody (YA8423) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GBP2.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 67 kDa
Full length human recombinant protein of human GBP2 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GBP2 is an Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to the protozoan pathogen Toxoplasma gondii. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins[1][2].
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Subcellular Localization
Cytoplasmic vesicle membrane,Golgi apparatus membrane,Cytoplasm,Cytoplasm, perinuclear region
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Expression
Induction: By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B
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Isoforms & Post-Translational Modification
P32456: 591 amino acids, molecular weight 67209 Da.
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Subunit
Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures (PubMed:21151871)
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SwissProt ID
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Synonyms
DKFZp451C2311
Documentation
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