GBP5 Antibody (YA8130)

Cat. No.: HY-P88446: Data Sheet COA
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GBP5 Antibody (YA8130) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GBP5.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

GBP5 Antibody (YA8130) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GBP5.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 66.4 kDa

Species Reactivity

Human

SwissProt ID

Q96PP8

Immunogen

Full length human recombinant protein of human GBP5 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000-3000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448)|Antigenic tumor-specific truncated splice form

Subcellular Localization：Cytoplasmic vesicle membrane,Golgi apparatus membrane,Cytoplasm

Expression：
Tissue_Specificity: Expressed in peripheral blood monocytes (at protein level)
Induction: By IFNG in endothelial cells and in LPS-primed macrophages

Isoforms & Post-Translational Modification：Q96PP8 has two isomers: Q96PP8-1: 66617 Da (predicted); Q96PP8-2: 55247 Da (predicted).
Isoprenylation is required for proper subcellular location

Subunit：Homodimer; homodimerizes upon GTP-binding, forming a close face-to-face dimer (PubMed:20180847, PubMed:21151871, PubMed:33876762)

Synonyms

GBP-5

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/a549-cell.html [Content Brief]