GCKR Antibody (YA8386)
(Synonyms: FGQTL5; GKRP)GCKR Antibody (YA8386) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GCKR.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 | 1:100-250 |
Product Details
GCKR Antibody (YA8386) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GCKR.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 68.5 kDa
Full length human recombinant protein of human GCKR produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GCKR regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity[1][2][3].
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Subcellular Localization
Cytoplasm,Nucleus,Mitochondrion
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Expression
Tissue_Specificity: Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen -
Isoforms & Post-Translational Modification
Q14397 has two isomers: Q14397-1: 68685 Da (predicted); Q14397-2: 16477 Da (predicted).
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Subunit
Interacts (fructose 6-phosphate bound form) with GCK
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SwissProt ID
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Synonyms
FGQTL5; GKRP
Documentation
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