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GIRK2 Antibody (YA6888)

(Synonyms: inwardly rectifying subfamily J member 6 antibody)
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Based on 1 Customer Validation

GIRK2 Antibody (YA6888) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GIRK2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP, IHC-F

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for GIRK2 Antibody (YA6888)
  • GIRK2 Antibody (YA6888) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
IHC-F Info
IHC-F: Immunohistochemistry-Frozen
Dilution Ratio 1:1000 1:1000 1-2μg/sample 1:500

Product Details

Description

GIRK2 Antibody (YA6888) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GIRK2.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat Predicted Reactivity: Cynomolgus monkey,Pig
    Info
    Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
  • Observed Molecular Weight
    Observed band size: 35/48 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size：48 kDa
Immunogen

Recombinant protein.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for GIRK2 Antibody (YA6888)
    Western blot analysis of extracts from MG-63 (lane 1(20μg, negative)) 、Mouse brain (lane 2(20μg)) and Rat brain (lane 3(20μg)) using GIRK2 Antibody (HY-P87200) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    GIRK2 is an Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors

  • Subcellular Localization

    Membrane

  • Expression


    Tissue_Specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas

  • Isoforms & Post-Translational Modification

    P48051: 423 amino acids, molecular weight 48451 Da.

  • Subunit

    Associates with KCNJ3/GIRK1 or KCNJ5/GRIK4 to form a G-protein-activated heteromultimer pore-forming unit

  • SwissProt ID

    P48051

  • Synonyms

    inwardly rectifying subfamily J member 6 antibody

GIRK2 Antibody (YA6888) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from MG-63 (lane 1(20μg, negative)) 、Mouse brain (lane 2(20μg)) and Rat brain (lane 3(20μg)) using GIRK2 Antibody (HY-P87200) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • GIRK2 Antibody (YA6888) Product Image
    1/16
  • Experimental Validation Results for GIRK2 Antibody (YA6888)
  • GIRK2 Antibody (YA6888) Product Image
  • Experimental Validation Results for GIRK2 Antibody (YA6888)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from MG-63 (lane 1(20μg, negative)) 、Mouse brain (lane 2(20μg)) and Rat brain (lane 3(20μg)) using GIRK2 Antibody (HY-P87200) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for GIRK2 Antibody (YA6888)
  • GIRK2 Antibody (YA6888) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from MG-63 (lane 1(20μg, negative)) 、Mouse brain (lane 2(20μg)) and Rat brain (lane 3(20μg)) using GIRK2 Antibody (HY-P87200) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • GIRK2 Antibody (YA6888) Product Image WB