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GLRB Antibody (YA4044)(PBS only)

(Synonyms: HKPX2)

GLRB Antibody (YA4044) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GLRB.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    ICC/IF, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • GLRB Antibody (YA4044)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

GLRB Antibody (YA4044) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GLRB.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 54 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 54 kDa
Immunogen

Purified recombinant fragment of human GLRB (AA: extra 23-160) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    GLRB is a Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents[1][2][3][4][5][6][7][8].

  • Subcellular Localization

    Postsynaptic cell membrane; Multi-pass membrane protein; Synapse; Cell projection, dendrite; Cell membrane; Multi-pass membrane protein; Cytoplasm

  • Isoforms & Post-Translational Modification

    P48167 has 2 isomers: P48167-1: 56122 Da (predicted); P48167-2: 34944 Da (predicted).

  • Subunit

    Forms heteropentamers with glycin receptor alpha subunits. Heteropentamers with GLRA1 can be composed of two GLRA1 and three GLRB subunits, or three GLRA1 and two GLRB subunits, or four GLRA1 subunits and one GLRB subunit (PubMed:11929858, PubMed:14551753, PubMed:22715885, PubMed:22973015, PubMed:23238346, PubMed:25445488, PubMed:8717357, PubMed:35526563, PubMed:37821459). Forms heteropentamers with GLRA2 (PubMed:15302677, PubMed:16144831, PubMed:25445488, PubMed:34473954). Functional GLRB-GLRA2 heteropentamers contain four GLRA2 subunits and one GLRB subunit, although alternative subunit composition cannot be excluded (PubMed:34473954). Forms a heteropentamer with GLRA3 (PubMed:25445488). Interacts with GPHN (PubMed:12684523, PubMed:26613940)

  • SwissProt ID

    P48167

  • Gene ID
    2743 [NCBI]
  • Synonyms

    HKPX2

GLRB Antibody (YA4044)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • GLRB Antibody (YA4044)(PBS only) Product Image