Glucagon Receptor Antibody
(Synonyms: Glucagon receptor, GL-R, GCGR)Glucagon Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Glucagon Receptor.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
Glucagon Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Glucagon Receptor.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 54 kDa
Synthetic peptide corresponding to the center region of human Glucagon Receptor.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Glucagon Receptor is a G protein-coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system[1][2].
-
Subcellular Localization
Cell membrane
-
Isoforms & Post-Translational Modification
Glucagon Receptor has an amino acid length of 477, molecular weight is 54009 Da.
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding. -
Subunit
Interacts with glucagon.
-
SwissProt ID
-
Synonyms
Glucagon receptor, GL-R, GCGR
Documentation
References
[1]. Qiao A, et al. Structural basis of G(s) and G(i) recognition by the human glucagon receptor. Science. 2020 Mar 20;367(6484):1346-1352. [Content Brief]
[2]. Cong Z, et al. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G(s) proteins. Cell Discov. 2024 Feb 13;10(1):18. [Content Brief]
Powered by Bioz
