GPR50 Antibody
(Synonyms: Melatonin-related receptor, G protein-coupled receptor 50, H9, GPR50)GPR50 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR50.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
GPR50 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR50.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 67 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 67 kDa
Synthetic peptide corresponding to the center region of human GPR50.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPR50 is a G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration[1][2][3].
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Subcellular Localization
Cell membrane; Postsynaptic density
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Expression
Tissue_Specificity: Hypothalamus and pituitary.
Induction: By TGFB. -
Isoforms & Post-Translational Modification
GPR50 has an amino acid length of 617, molecular weight is 67369 Da.可被 CAPN1 以钙依赖的方式切割GPR50 的氨基酸个数为 617 个，分子量为 67369 Da。Cleaved by CAPN1 in a calcium-dependent manner
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Subunit
Homodimer, and heterodimer with MTNR1A and MTNR1B.
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SwissProt ID
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Synonyms
Melatonin-related receptor, G protein-coupled receptor 50, H9, GPR50
Documentation
[1]. Grünewald E, et al. GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol Cell Neurosci. 2009 Dec;42(4):363-71. [Content Brief]
[2]. Li J, et al. GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling. PLoS One. 2011;6(8):e23725. [Content Brief]
[3]. Wojciech S, et al. The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development. Nat Commun. 2018 Mar 23;9(1):1216. [Content Brief]
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