GPR50 - G protein-coupled receptor 50 Gene

Also Known as H9; Mel1c

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9248

About GPR50

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,176,584-151,182,856 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 33 paralogues. Low expression observed in reference dataset.

Summary

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits Melatonin Receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

GPR50 Products (1)

mRNA Protein Name
NM_004224.3 NP_004215.2 melatonin-related receptor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16778767 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR50 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (45 - 294)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

melatonin-related receptor

GPR50 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR50 Q13585 ZNF572 Homo sapiens Q7Z3I7
Y2H Prey Pooling
25416956
Intra
GPR50 Q13585 MT1A Homo sapiens P04731
IF
16778767
Intra
GPR50 Q13585 MT1A Homo sapiens P04731
BRET
16778767
Intra
GPR50 Q13585 MT1A Homo sapiens P04731
Anti Tag CoIP
16778767
Cross: Cross-species interaction Intra: Intraspecies interaction

GPR50 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810961 GPR50 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Pituitary Adenoma 2, Growth Hormone-Secreting

  • PITA2

  • Acromegaly Due To Pituitary Adenoma 2

  • Acromegaly, X-Linked

  • Growth Hormone Secreting Pituitary Adenoma 2

  • Pituitary Adenoma, Growth Hormone-Secreting, 2

  • Pituitary Adenoma 2, Gh-Secreting

  • Gh-Secreting Pituitary Adenoma 2

  • X-Linked Acromegaly

  • Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

  • Mrxs13

  • Lindsay-Burn Syndrome

  • Ppm-X

  • Ppm-X Syndrome

  • Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism

  • Mental Retardation, X-Linked, Syndromic 13

  • X-Linked Mental Retardation 79

  • X-Linked Mental Retardation With Spasticity

  • Intellectual Deficit, X-Linked - Psychosis - Macroorchidism

  • Intellectual Disability Psychosis Macroorchidism

  • Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism

  • Intellectual Disability, X-Linked, Syndromic 13

  • Ppmx

  • X-Linked Mental Retardation, Syndromic 13
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05717 GPR50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20942 Gpr50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27459 Gpr50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPR50 MGD MGI:1333877
Macaca mulatta GPR50 VGNC VGNC:73138
Canis familiaris GPR50 VGNC VGNC:41437
Rattus norvegicus GPR50 RGD RGD:619863
Bos taurus GPR50 VGNC VGNC:29589
Others GPR50 NCBI