H6PD Antibody (YA7845)(PBS only)
(Synonyms: CORTRD1; G6PDH; GDH)H6PD Antibody (YA7845) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to H6PD.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-250 | 1:100-250 | 1:100 |
Product Details
H6PD Antibody (YA7845) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to H6PD.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 88.7 kDa
Full length human recombinant protein of human H6PD produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG2b
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Shipping
Shipping with blue ice.
Background
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Function
H6PD is a Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity[1][2][3].
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Subcellular Localization
Endoplasmic reticulum lumen
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Expression
Tissue_Specificity: Present in most tissues examined, strongest in liver -
Isoforms & Post-Translational Modification
O95479 has two isomers: O95479-1: 88893 Da (predicted); O95479-2: 90173 Da (predicted).
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Subunit
Homodimer
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SwissProt ID
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Synonyms
CORTRD1; G6PDH; GDH
Documentation
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