HSPA6 Antibody (YA7825)(PBS only)
(別名: heat shock 70kDa protein 6 (HSP70B'); heat shock 70kD protein 6 (HSP70B'))HSPA6 Antibody (YA7825) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HSPA6.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
HSPA6 Antibody (YA7825) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HSPA6.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 70.8 kDa
Full length human recombinant protein of human HSPA6 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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輸送条件
Shipping with blue ice.
Background
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Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365)
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Expression
Induction: Only at higher temperatures, and no basal expression
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Isoforms & Post-Translational Modification
P17066: 643 amino acids, molecular weight 71028 Da.
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SwissProt ID
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別名
heat shock 70kDa protein 6 (HSP70B'); heat shock 70kD protein 6 (HSP70B')
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