HtrA2/Omi Antibody (YA3536)
(Synonyms: OMI; MGCA8; PARK13; PRSS25)HtrA2/Omi Antibody (YA3536) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HtrA2/Omi.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
HtrA2/Omi Antibody (YA3536) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HtrA2/Omi.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Purified recombinant fragment of human HTRA2 (AA: 278-458) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HtrA2/Omi serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis; Seems to be proteolytically inactive[1][2][3][4][5].
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Subcellular Localization
Mitochondrion intermembrane space; Mitochondrion membrane; Single-pass membrane protein; Endoplasmic reticulum
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Expression
Tissue_specificity:general expression -
Isoforms & Post-Translational Modification
O43464 has 4 isomers: O43464-1: 48841 Da (predicted); O43464-2: 38493 Da (predicted); O43464-3: 46382 Da (predicted); O43464-4: 39914 Da (predicted).
Ubiquitinated by BIRC6; this activity is inhibited by DIABLO/SMAC;Autoproteolytically activated -
Subunit
Homotrimer (PubMed:36758104, PubMed:36758105). Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (PubMed:23479728)
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SwissProt ID
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Synonyms
OMI; MGCA8; PARK13; PRSS25
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