Human IgG4 Antibody (YA3327)

Art. -Nr.: HY-P83582: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Human IgG4 Antibody (YA3327) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG4.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Größe	Verfügbarkeit	Menge
20 μL	Auf Lager	Estimated Time of Arrival: December 31
50 μL	Auf Lager	Estimated Time of Arrival: December 31
100 μL	Auf Lager	Estimated Time of Arrival: December 31
250 μL	Angebot einholen

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Human IgG4 Antibody (YA3327) Spezialitätsempfehlungen:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

Human IgG4 Antibody (YA3327) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human IgG4.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molekulargewicht

Predicted band size: 36 kDa;

Observed band size: 36 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P01861

Gene ID

3503 [NCBI]

Immunogen

A synthesized peptide derived from human IgG4 aa95-109.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-1:5000

Sensitivity	Endogenous	Reinheit	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)

Subcellular Localization：Secreted; Cell membrane; Single-pass membrane protein

Isoforms & Post-Translational Modification：P01861 has 2 isomers: P01861-2: 43832 Da (predicted); P01861-1: 35941 Da (predicted).
Glycosylation on Asn-177 is required for interaction with Fc receptors and ability to activate the complement pathway;(Microbial infection) Deglycosylation on Asn-177 by S.pyogenes EndoS or Endos2 endoglucosidases prevents interaction between immunoglobulin-gamma (IgG) and Fc receptors, impairing ability to activate the complement pathway

Subunit：Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked

Database

Entrez Gene: 3503 Human

SwissProt: P01861 Human

OMIM: 147130 Human

Research Field

Immunology

Synonyms

IGG4; Ig gamma 4 chain C region

Dokumentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Human IgG4 Antibody (YA3327) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Human IgG4 Antibody (YA3327)

Human IgG4 Antibody (YA3327) Spezialitätsempfehlungen:

Product Detail

Background

Beschreibung

Human IgG4 Antibody (YA3327) Related Classifications

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