IL-15 Antibody (YA10043)
(Synonyms: Interleukin-15, IL-15, IL15)IL-15 Antibody (YA10043) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to IL-15.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:50-200 | 1:500-2000 |
Product Details
IL-15 Antibody (YA10043) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to IL-15.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant protein of human IL-15.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-15 is a Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity)[1][2][3][4][5][6][7].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Induction: By interferon-gamma. -
Isoforms & Post-Translational Modification
IL-15 has 2 isoforms, P40933-1: amino acid length is 162, molecular weight is 18086 Da (predicted); P40933-2: amino acid length is 135, molecular weight is 14912 Da (predicted).
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SwissProt ID
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Synonyms
Interleukin-15, IL-15, IL15
Documentation
References
[1]. Ratthé C, et al. Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J Leukoc Biol. 2004 Jul;76(1):162-8. [Content Brief]
[2]. Grabstein KH, et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science. 1994 May 13;264(5161):965-8. [Content Brief]
[3]. Badolato R, et al. Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood. 1997 Oct 1;90(7):2804-9. [Content Brief]
[4]. Musso T, et al. Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15. Blood. 1999 May 15;93(10):3531-9. [Content Brief]
[5]. Ring AM, et al. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol. 2012 Dec;13(12):1187-95. [Content Brief]
[6]. Giri JG, et al. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 1994 Jun 15;13(12):2822-30. [Content Brief]
[7]. Johnston JA, et al. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8705-9. [Content Brief]
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