IL-1 alpha Antibody (YA4914)
(Synonyms: IL1A; IL1F1; Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1)IL-1 alpha Antibody (YA4914) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-1 alpha.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:50-1:200 | 1:50-1:100 |
Product Details
IL-1 alpha Antibody (YA4914) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-1 alpha.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant fragment of human IL1A expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-1 alpha is a major agonist of IL-1 and also is a pro-inflammatory cytokine. IL-1 alpha acts as an ‘alarmin’ and as a primum movens of tissue inflammation[1]. IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation[2]. IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation[3]. IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes[4].
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Subcellular Localization
Nucleus; Cytoplasm; Secreted
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Subunit
Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059). Interacts with IL1R1 (PubMed:2950091). Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane (PubMed:21270123)
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SwissProt ID
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Synonyms
IL1A; IL1F1; Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1
Documentation
References
[2]. Cook SA, et al. Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation. Annu Rev Med. 2020 Jan 27;71:263-276. [Content Brief]
[3]. Balakrishnan L, et al. IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Cell Commun Adhes. 2013 Aug;20(3-4):81-6 [Content Brief]
[4]. Dams-Kozlowska H, et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC Biotechnol. 2012 Mar 21;12:8. [Content Brief]
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