ITIH4 70k Antibody
(Synonyms: IHRP, ITIHL1, PK120, PRO1851, ITIH4, Inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, Plasma kallikrein sensitive glycoprotein 120, Gp120, PK-120)ITIH4 70k Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ITIH4 70k.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
ITIH4 70k Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ITIH4 70k.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 103; 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 103 kDa
Synthetic peptide corresponding to the center region of human ITIH4 70k.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ITIH4 70k is a Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Liver specific.
Induction: Levels increase from 1.4 to 3-fold in acute-phase processes such as in acute ischemia stroke (AIS), unstable angina and programmed surgery. In hepatocytes, induced by IL6 but not by other cytokines such as IL1B. -
Isoforms & Post-Translational Modification
ITIH4 70k has 4 isoforms, Q14624-1: amino acid length is 930, molecular weight is 103357 Da (predicted); Q14624-2: amino acid length is 914, molecular weight is 101241 Da (predicted); Q14624-3: amino acid length is 900, molecular weight is 99857 Da (predicted); Q14624-4: amino acid length is 845, molecular weight is 93852 Da (predicted).
Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. -
Subunit
Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro
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SwissProt ID
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Synonyms
IHRP, ITIHL1, PK120, PRO1851, ITIH4, Inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, Plasma kallikrein sensitive glycoprotein 120, Gp120, PK-120
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