ITIH4 - inter-alpha-trypsin inhibitor heavy chain 4 Gene

Also Known as H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3700

About ITIH4

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,812,962-52,830,672 (from NCBI)

This gene has 14 transcripts (splice variants), 121 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 556.7).

Summary

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma Kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

ITIH4 Products (2)

mRNA	Protein	Name
NM_001166449.2	NP_001159921.1	inter-alpha-trypsin inhibitor heavy chain H4 isoform 2 precursor
NM_002218.5	NP_002209.2	inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16271702	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	19263524	GOA
involved in response to cytokine	IEP IEP: Inferred from expression pattern	10486281	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITIH4 Protein Structure

VIT

VWA

ITI_HC_C

0
200
400
600
800
930 a.a.

Protein Preferred Names	Protein Names
inter-alpha-trypsin inhibitor heavy chain H4	ITI heavy chain H4

ITIH4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811044	ITIH4 70k Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89650	ITI-H4 Antibody (YA8994)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Aids Dementia Complex	Adc Aids Related Cognitive Impairment
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Scrapie
Retinitis Pigmentosa 71	RP71 Retinitis Pigmentosa, Type 71
Opioid Abuse	Opioid-Related Disorders
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Double Pterygium
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Cardiogenic Shock	Shock Cardiogenic Shock, Cardiogenic
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06977	ITIH4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22578	Itih4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29096	Itih4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ITIH4	VGNC	VGNC:73796
Mus musculus	ITIH4	MGD	MGI:109536
Canis familiaris	ITIH4	VGNC	VGNC:42147
Felis catus	ITIH4	VGNC	VGNC:67862
Bos taurus	ITIH4	VGNC	VGNC:30336
Rattus norvegicus	ITIH4	RGD	RGD:70881
Others	ITIH4	NCBI