KLHL2 Antibody (YA8500)
(Synonyms: ABP-KELCH; MAV; MAYVEN)KLHL2 Antibody (YA8500) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLHL2.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-250 | 1:100 |
Product Details
KLHL2 Antibody (YA8500) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KLHL2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 65.8 kDa
Human recombinant protein fragment corresponding to amino acids 1-100 and 494-593 of human KLHL2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KLHL2 is a Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation. The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton,Cell projection, ruffle,Cell projection,Cell projection, lamellipodium,Cytoplasm, cytosol
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Expression
Tissue_Specificity: Ubiquitous. Detected throughout the brain -
Isoforms & Post-Translational Modification
O95198 has three isomers: O95198-1: 65975 Da (predicted); O95198-2: 66624 Da (predicted); O95198-3: 56086 Da (predicted).
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Subunit
Component of the BCR(KLHL2) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL2 and RBX1 (PubMed:23838290)
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SwissProt ID
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Synonyms
ABP-KELCH; MAV; MAYVEN
Documentation
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