KMT2D Antibody (YA3502)(PBS only)
(Synonyms: ALR; KMS; MLL2; MLL4; AAD10; KABUK1; TNRC21; CAGL114)KMT2D Antibody (YA3502) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KMT2D.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
KMT2D Antibody (YA3502) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KMT2D.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 593 kDa
Purified recombinant fragment of human KMT2D (AA: 445-599) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KMT2D is a Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription[1][2][3].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver -
Isoforms & Post-Translational Modification
O14686 has 2 isomers: O14686-1: 593389 Da (predicted); O14686-3: 593677 Da (predicted).
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Subunit
Component of the MLL2 complex (also named ASCOM complex), at least composed of catalytic subunit KMT2D/MLL2, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:12482968, PubMed:16603732, PubMed:17021013, PubMed:17500065, PubMed:17761849, PubMed:17851529, PubMed:23508102). Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity (PubMed:25561738). Interacts with ESR1; interaction is direct (PubMed:16603732). Interacts (via WIN motif) with WDR5 (PubMed:22266653, PubMed:22665483)
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SwissProt ID
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Synonyms
ALR; KMS; MLL2; MLL4; AAD10; KABUK1; TNRC21; CAGL114
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