LDLRAP1 (ARH) Antibody (YA8055)
(Synonyms: ARH; ARH1; ARH2; FHCB1; FHCB2)LDLRAP1 (ARH) Antibody (YA8055) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LDLRAP1 (ARH).
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
LDLRAP1 (ARH) Antibody (YA8055) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LDLRAP1 (ARH).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 33.7 kDa
Full length human recombinant protein of human LDLRAP1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LDLRAP1 is an Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes -
Isoforms & Post-Translational Modification
Q5SW96: 308 amino acids, molecular weight 33885 Da.
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Subunit
Interacts (via PID domain) with LDLR (via NPXY motif) (PubMed:12221107)
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SwissProt ID
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Synonyms
ARH; ARH1; ARH2; FHCB1; FHCB2
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