LIN7B Antibody (YA8433)
(Synonyms: LIN-7B; MALS-2; MALS2; VELI2)LIN7B Antibody (YA8433) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIN7B.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 | 1:100-250 | 1:100 |
Product Details
LIN7B Antibody (YA8433) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIN7B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 22.7 kDa
Full length human recombinant protein of human LIN7B produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LIN7B plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface
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Subcellular Localization
Cell membrane,Basolateral cell membrane,Cell junction,Postsynaptic density membrane,Cell junction, tight junction
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Isoforms & Post-Translational Modification
Q9HAP6 has two isomers: Q9HAP6-1: 22896 Da (predicted); Q9HAP6-2: 15620 Da (predicted).
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Subunit
Forms a complex with CASK and CASKIN1 (By similarity)
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SwissProt ID
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Synonyms
LIN-7B; MALS-2; MALS2; VELI2
Documentation
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