MAGE-3 Antibody (YA4021)
(Synonyms: HIP8; HYPD; CT1.3; MAGE3; MAGEA6)MAGE-3 Antibody (YA4021) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAGE-3.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
MAGE-3 Antibody (YA4021) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAGE-3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 35 kDa
Purified recombinant fragment of human MAGE-3 (AA: FLWGPRALVC) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAGE-3 is an Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes[1][2][3][4].
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Expression
Tissue_specificity:This gene is expressed in various types of tumors, such as melanoma, head and neck squamous cell carcinoma, lung cancer, and breast cancer, but not in normal tissues except for the testes and placenta. It has never been expressed in kidney tumors, leukemia, and lymphoma. -
Subunit
Interacts with TRIM28
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SwissProt ID
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Synonyms
HIP8; HYPD; CT1.3; MAGE3; MAGEA6
Documentation
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