MBNL1 Antibody (YA7257)
MBNL1 Antibody (YA7257) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
FC
-
Reactivity :
Human
-
Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
|---|---|
| Dilution Ratio | 1:50-100 |
Product Details
MBNL1 Antibody (YA7257) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman Predicted Reactivity: Mouse
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
-
Observed Molecular WeightObserved band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 42 kDa
A synthesized peptide derived from human MBNL1
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
MBNL1 mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events. Regulates NCOR2 alternative splicing[1].
-
Subcellular Localization
Nucleus,Cytoplasm,Cytoplasmic granule
-
Expression
Tissue_Specificity: Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas -
Isoforms & Post-Translational Modification
Q9NR56 has 7 isomers: Q9NR56-1: 41817 Da (predicted); Q9NR56-2: 39831 Da (predicted); Q9NR56-3: 33050 Da (predicted); Q9NR56-4: 34211 Da (predicted); Q9NR56-5: 40992 Da (predicted); Q9NR56-6: 37074 Da (predicted); Q9NR56-7: 36992 Da (predicted).
-
Subunit
Interacts with DDX1 and YBX1
-
SwissProt ID
Documentation
Powered by Bioz
