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Cat. No.: HY-P84372A

MECP2 Antibody (YA4069)(PBS only)

Name: MECP2 Antibody (YA4069)(PBS only)
Brand: MedChemExpress
SKU: HY-P84372A
Availability: PreOrder

(Synonyms: RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13)

MECP2 Antibody (YA4069) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MECP2.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:200-1:1000	1:200-1:400	1:10000

Description

MECP2 Antibody (YA4069) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MECP2.

Host Mouse
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 52 kDa

Immunogen

Purified recombinant fragment of human MECP2 (AA: 7-148) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

MECP2 is a Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)
Subcellular Localization

Nucleus
Expression

Tissue_specificity:It is present in all examined adult somatic tissues.
Isoforms & Post-Translational Modification

P51608 has 2 isomers: P51608-1: 52441 Da (predicted); P51608-2: 53323 Da (predicted).
Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation
Subunit

Interacts with FNBP3 (By similarity). Interacts with CDKL5 (PubMed:15917271). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells (By similarity). Interacts with NCOR2 (By similarity). Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1 (PubMed:28348241). Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (PubMed:28348241)
SwissProt ID

P51608
Gene ID

4204 [NCBI]
Synonyms

RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13