MGRN1 Antibody (YA8516)
(Synonyms: RNF156)MGRN1 Antibody (YA8516) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MGRN1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
MGRN1 Antibody (YA8516) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MGRN1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 63 kDa
Full length human recombinant protein of human MGRN1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MGRN1 is an E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling
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Subcellular Localization
Early endosome,Cytoplasm, cytosol,Nucleus,Cytoplasm, cytosol,Nucleus,Cytoplasm, cytosol,Cell membrane,Cytoplasm, cytosol,Cell membrane
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Isoforms & Post-Translational Modification
O60291 has four isomers: O60291-1: 60753 Da (predicted); O60291-2: 63190 Da (predicted); O60291-3: 60742 Da (predicted); O60291-4: 58305 Da (predicted).
Autoubiquitinated in vitro -
Subunit
Interacts with MC1R and MC4R, but not with TBXA2R
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SwissProt ID
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Synonyms
RNF156
Documentation
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