MOBKL1A (MOB4A) Antibody (YA8541)
(Synonyms: MATS2; MOB4A; MOBKL1A)MOBKL1A (MOB4A) Antibody (YA8541) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MOBKL1A (MOB4A).
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:100 | 1:150-500 |
Product Details
MOBKL1A (MOB4A) Antibody (YA8541) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MOBKL1A (MOB4A).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 24.9 kDa
Full length human recombinant protein of human MOBKL1A produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MOBKL1A is an Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver -
Isoforms & Post-Translational Modification
Q7L9L4 has two isomers: Q7L9L4-1: 25091 Da (predicted); Q7L9L4-2: 25499 Da (predicted).
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1 -
Subunit
Binds STK38L
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SwissProt ID
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Synonyms
MATS2; MOB4A; MOBKL1A
Documentation
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