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  5. MRP1 Antibody (YA1583)

MRP1 Antibody (YA1583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP1.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

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제품 설명

MRP1 Antibody (YA1583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
분자량
Predicted band size: 172 kDa;
Observed band size: 250 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human MRP1 aa1500-1531.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Verification Image
WB

  • Western blot analysis was performed on extracts from A549 (lane 1, 20 μg), K562 (lane 2, 20 μg), HepG2 (lane 3, 20 μg), A431 (lane 4, 20 μg), 3T3 (lane 5, 20 μg), and Hela (lane 6, 20 μg) using MRP1 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Tubulin, HY-P80955, 1:5000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit/Mouse IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background
Function：Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231)
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Multi-pass membrane protein
Expression：
Tissue_specificity:Lung, testis and peripheral blood mononuclear cells
Isoforms & Post-Translational Modification：P33527 has 9 isomers: P33527-1: 171591 Da (predicted); P33527-2: 164971 Da (predicted); P33527-3: 165569 Da (predicted); P33527-4: 164304 Da (predicted); P33527-5: 158949 Da (predicted); P33527-6: 157683 Da (predicted); P33527-7: 158282 Da (predicted); P33527-8: 151661 Da (predicted); P33527-9: 172640 Da (predicted).
Subunit：(Microbial infection) Interacts with human cytomegalovirus protein UL138; this interaction mediates MRP1 degradation via the lysosome
RRID
Database

Entrez Gene: 4363 Human

SwissProt: P33527 Human

OMIM: 618915 Human

Research Field

Signal Transduction
Synonyms
ABC29; Abcc1; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP1
각종 서류
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

MRP1 Antibody (YA1583) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
MRP1 Antibody (YA1583)
Cat. No.:
HY-P81838
수량:
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