MRP1 Antibody (YA7186)

Cat. No.: HY-P87501: Data Sheet User Guide for Antibodies
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MRP1 Antibody (YA7186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP1.

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사이즈	재고	수량
20 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	견적 받기

Synthetic products have potential research and development risk.

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

MRP1 Antibody (YA7186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP1.

Host

Rabbit

Clonality

Monoclonal,Recombinant

분자량

Predicted band size: 172 kDa;

Observed band size: 250 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P33527

Gene ID

4363 [NCBI]

Immunogen

Synthetic peptide within Human MRP1 aa 1482-1531 / 1531.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1,000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:200
FC FC: Flow Cytometry	1:1,000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA

Subcellular Localization：Endoplasmic reticulum,Endoplasmic reticulum-Golgi intermediate compartment,Nucleus,Cytoplasm,Cell membrane

Expression：
Tissue_Specificity: Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta
Induction: Up-regulated by IL4/interleukin-4 (at protein level)

Positive sample: A549 cell lysate, HepG2 cell lysate, A549, human pancreas tissue, human tonsil tissue.

Isoforms & Post-Translational Modification：P17706 has four isomers: P17706-1: 48473 Da (predicted); P17706-2: 45168 Da (predicted); P17706-3: 40990 Da (predicted); P17706-4: 48017 Da (predicted).
Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2

Subunit：Interacts with RMDN3

Database

Entrez Gene: 4363 Human

SwissProt: P33527 Human

Research Field

Signal Transduction

Synonyms

ABC29; Abcc1; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP1

각종 서류

User Guide for Antibodies (1077 KB)