MUC6 Antibody (YA5733)
(Synonyms: Mucin-6; MUC-6; Gastric mucin-6; )
Based on 1 Customer Validation
MUC6 Antibody (YA5733) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUC6.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-400 | 1:50-200 | 1:500-5000 |
Product Details
MUC6 Antibody (YA5733) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUC6.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 257 kDa;
Synthesized peptide derived from human MUC6 AA range: 1000-1100
affinity chromatography.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Mucin 6 (MUC6) is a secreted gel-forming mucin that constitutes a major component of gastric mucus and is predominantly expressed in the deep gastric glands, particularly the pyloric and mucous neck gland compartments[1][2][3]. MUC6 contributes to the organization of the gastric mucus barrier together with MUC5AC, forming a protective mucosal system that supports resistance to gastric acid, pepsin, and microbial challenge[4][5][6]. Mechanistically, the heavily glycosylated structure of MUC6 participates in the formation of a viscoelastic mucus layer, and its carbohydrate side chains interact with bicarbonate and other protective factors that help maintain mucosal integrity[4][5]. In gastric physiology, MUC6 exhibits a distinct expression pattern compared with the related gastric mucin MUC5AC, which is primarily localized to the superficial foveolar epithelium, whereas MUC6 is concentrated within glandular regions[1][2][3][7]. This spatial specialization makes MUC6 a useful marker for defining gastric epithelial differentiation and gastric-type mucin phenotypes in experimental pathology studies[7]. Altered MUC6 expression has been reported during gastric carcinogenesis and other gastric pathological conditions, supporting its utility as a biomarker in studies of disease progression and mucosal transformation[4][8][9]. Experimental evidence further indicates that enhancement of MUC6 expression accompanies cytoprotective responses in gastric injury models, where increased MUC6 production is associated with reinforcement of the mucus barrier[10].
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:It is expressed in the regeneration zone of the gastric antrum, the mucosa of the gastric body, and the mucosa of the gastric notch. It is also expressed in the deep mucous glands of the gastric antrum. It is overexpressed in gastric epithelium infected with Helicobacter pylori. It is highly expressed in the Brenner's glands of the duodenum, gallbladder, seminal vesicle, central cells and ducts of the pancreatic acinar, and glands surrounding the common bile duct.
Induction:Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors -
Subunit
Multimer; disulfide-linked
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SwissProt ID
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Synonyms
Mucin-6; MUC-6; Gastric mucin-6;
Documentation
[1]. Reis CA, et al. Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. J Histochem Cytochem. 2000 Mar;48(3):377-88. [Content Brief]
[2]. Nordman H, et al. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J. 2002 May 15;364(Pt 1):191-200. [Content Brief]
[3]. Niv Y. Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis. World J Gastroenterol. 2015 Aug 21;21(31):9430-6. doi: 10.3748/wjg.v21.i31.9430. PMID: 26309370; PMCID: PMC4541396. et al. Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis. World J Gastroenterol. 2015 Aug 21;21(31):9430-6. [Content Brief]
[4]. Miao L, et al. Unique immunohistochemical profiles of MUC5AC, MUC6, P53, and Ki67 in gastric atypical hyperplasia and dysplasia. Int J Clin Exp Pathol. 2024 Mar 15;17(3):63-71. [Content Brief]
[10]. Nam SY, et al. Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. Dig Dis Sci. 2005 Nov;50(11):2110-20. [Content Brief]
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