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  5. Mucin 5B Antibody (YA3532)

Mucin 5B Antibody (YA3532)

Cat. No.: HY-P80990
User Guide for Antibodies Technical Support

Mucin 5B Antibody (YA3532) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mucin 5B.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Mucin 5B Antibody (YA3532) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mucin 5B.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 596 kDa;
Observed band size: 596 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant fragment of human MUC5B expressed in E. Coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Conjugation Non-conjugated
Modification Unmodified Isotype IgG1
Appearance

Liquid
Formulation

Supplied in PBS with 0.05% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Background
Function：Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus
Subcellular Localization：Secreted
Expression：
Tissue_specificity:It is expressed on the surface epithelial cells of the respiratory tract. It is mainly expressed in the mucous cells of the submucosal glands of the respiratory tract. It is highly expressed in the sublingual glands. It is also found in the submandibular glands, cervical endometrium, gallbladder, and pancreas.

Induction:Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner
Subunit：Homomultimer; disulfide-linked (PubMed:31570524). The N- and C-terminus mediate their assembly into higher order structures to form filaments (By similarity). The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers (PubMed:31570524). These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum (By similarity). Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion (By similarity)
Database

Entrez Gene: 727897 Human

SwissProt: Q9HC84 Human

OMIM: 178500 Human

Research Field

Signal Transduction
Documentation
User Guide for Antibodies (1077 KB)

Mucin 5B Antibody (YA3532) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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