MUC5B - mucin 5B, oligomeric mucus/gel-forming Gene

Also Known as MG1; MUC5; MUC9; MUC-5B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 727897

About MUC5B

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,223,066-1,262,172 (from NCBI)

This gene has 5 transcripts (splice variants), 151 orthologues, 19 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 56.3), colon (RPKM 19.6) and 3 other tissues.

Summary

This gene encodes a member of the Mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming Mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

MUC5B Products (1)

mRNA	Protein	Name
NM_002458.3	NP_002449.2	mucin-5B precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1718282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC5B Protein Structure

VWD

TIL

VWD

TIL

VWD

Mucin2_WxxW

VWD

VWC

0
900
1800
2700
3600
4500
5400
5762 a.a.

Protein Preferred Names	Protein Names
mucin-5B	cervical mucin MUC5B

MUC5B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80990	Mucin 5B Antibody (YA3532)	IHC-P, FC	Human
HY-P84810	Mucin 5B Antibody (YA4507)	IHC-P, FC, ELISA	Human
HY-P84810A	Mucin 5B Antibody (YA4507)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Panbronchiolitis, Diffuse	Diffuse Panbronchiolitis Dpb Pblt
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Pulmonary Fibrosis	Fibrosis Of Lung
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Asbestosis	Idiopathic Interstitial Pneumonitis - From Asbestos Exposure Pulmonary Fibrosis - From Asbestos Exposure
Bile Duct Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of The Bile Duct Extrahepatic Bile Duct Mucoepidermoid Carcinoma
Colloid Carcinoma Of The Pancreas
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Intrahepatic Biliary Papillomatosis	Intrahepatic Bile Duct Papillary Neoplasm
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Chronic Ethmoiditis	Chronic Ethmoidal Sinusitis Chronic Ethmoid Sinusitis Ethmoidal Sinusitis - Chronic
Lung Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Lung
Bile Duct Mucinous Adenocarcinoma	Mucinous Carcinoma Of The Bile Duct Extrahepatic Bile Duct Mucinous Adenocarcinoma
Anthracosis	Black Lung Coal Workers' Pneumoconiosis Melanoedema Black Lung Disease Pneumoconiosis Coal Miner'S Pneumoconiosis Coal Workers' Lung Coal Worker'S Pneumoconiosis Coal Workers Pneumoconiosis Coal Miners' Lung Coal Miners' Pneumoconiosis Coal Pneumoconiosis Colliers' Anthracosis Colliers' Lung Lung Melanosis Miners' Asthma Miners' Lung Pneumomelanosis Cwp - [Coalworkers Pneumoconiosis] Fibrosis Of Lung With Anthracosilicosis Lung Fibrosis With Anthracosis Miners' Pneumoconiosis Carbon Lung Coalworker Lung Collier'S Asthma Anthracosilicosis Lung Anthracosis
Biliary Papillomatosis	Bile Duct Papillomatosis
Rheumatoid Arthritis Interstitial Lung Disease	Rheumatoid Lung
Interstitial Pneumonitis, Desquamative, Familial	Desquamative Interstitial Pneumonia DIP Pneumonitis, Desquamative Interstitial, Familial Pneumonia, Desquamative Interstitial, Familial Interstitial Lung Disease, Desquamative Ild, Desquamative Familial Desquamative Interstitial Pneumonitis Rbild Respiratory Bronchiolitis-Associated Interstitial Lung Disease Respiratory Bronchiolitis Associated Interstitial Lung Disease
Chronic Purulent Otitis Media	Chronic Suppurative Otitis Media Csom - [Chronic Suppurative Otitis Media]
Suppurative Otitis Media	Otitis Media With Effusion - Purulent Purulent Otitis Media Otitis Media, Suppurative
Middle Ear Disease	Middle Ear Anomaly Disorder Of Middle Ear
Bile Duct Cystadenocarcinoma	Biliary Cystadenocarcinoma Intrahepatic Bile Duct Cystadenocarcinoma Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma
Bird Fancier'S Lung	Bird Fancier Lung Pigeon Breeder'S Lung Avian Hypersensitivity Pneumonitis Bird Breeder'S Lung Bird-Fancier'S Lung Bird-Fanciers' Lung Poultry Worker'S Lung Pigeon-Breeder Lung Disease Pigeon Breeders Lung Avian Protein Hypersensitivity Bird Breeders' Disease Bird Breeders' Lung Bird Fanciers' Lung Bird Fanciers' Disease Bfl - [Bird Fancier Lung] Fanciers' Disease Fanciers' Lung
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Acute Interstitial Pneumonia	Acute Interstitial Pneumonitis Hamman-Rich Syndrome Accelerated Interstitial Pneumonia Aip Hamman-Rich Disease Idiopathic Pulmonary Fibrosis, Acute Fatal Form Idiopathic Pulmonary Fibrosis
Enamel Erosion
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Acute Asthma
Complement Component 7 Deficiency	C7 Deficiency C7D
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08845	MUC5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20449	Muc5b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26958	Muc5b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MUC5B	MGD	MGI:1921430
Rattus norvegicus	MUC5B	RGD	RGD:1561983
Macaca mulatta	MUC5B	VGNC	VGNC:75081
Canis familiaris	MUC5B	VGNC	VGNC:49928