NFKBIZ Antibody (YA7965)(PBS only)

Cat. No.: HY-P88281A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

NFKBIZ Antibody (YA7965) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NFKBIZ.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NFKBIZ Antibody (YA7965) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NFKBIZ.

Host

Mouse

Molecular Weight

Predicted band size: 77.9 kDa

Species Reactivity

Human

SwissProt ID

Q9BYH8

Immunogen

Full length human recombinant protein of human NFKBIZ produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Also seems to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart
Induction: By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS)

Isoforms & Post-Translational Modification：Q9BYH8 has three isomers: Q9BYH8-1: 78061 Da (predicted); Q9BYH8-2: 68245 Da (predicted); Q9BYH8-3: 64298 Da (predicted).

Subunit：Interacts with NFKB1/p50 (PubMed:16513645)

Synonyms

IKBZ; INAP; MAIL

Documentation

User Guide for Antibodies (1077 KB)