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NFKBIZ Antibody (YA7965)(PBS only)

(Synonyms: IKBZ; INAP; MAIL)

NFKBIZ Antibody (YA7965) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NFKBIZ.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NFKBIZ Antibody (YA7965)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100

Product Details

Description

NFKBIZ Antibody (YA7965) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NFKBIZ.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 77.9 kDa
Immunogen

Full length human recombinant protein of human NFKBIZ produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NFKBIZ is involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR)[1][2].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_Specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart
    Induction: By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS)

  • Isoforms & Post-Translational Modification

    Q9BYH8 has three isomers: Q9BYH8-1: 78061 Da (predicted); Q9BYH8-2: 68245 Da (predicted); Q9BYH8-3: 64298 Da (predicted).

  • Subunit

    Interacts with NFKB1/p50 (PubMed:16513645)

  • SwissProt ID

    Q9BYH8

  • Synonyms

    IKBZ; INAP; MAIL

NFKBIZ Antibody (YA7965)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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