Osteoprotegerin Antibody (YA4998)
(Synonyms: TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin)Osteoprotegerin Antibody (YA4998) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Osteoprotegerin.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Osteoprotegerin Antibody (YA4998) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Osteoprotegerin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 60 kDa;
Purified recombinant fragment of SRA expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Osteoprotegerin (OPG) belongs to TNF receptor superfamily. OPG is expressed in many tissues besides osteoblasts, including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin plays a critical role in bone remodeling, and has osteoprotective effect. Osteoprotegerin also protects large blood vessels from medial calcification. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis[1]. OPG is also involved in multiple processes of cancers, such as tumor survival, epithelial to mesenchymal transition (EMT), neo-angiogenesis, invasion, and metastasis. Human osteoprotegerin shares <85% aa sequence identity with mouse and rat. Mouse OX40 shares 94.5% aa sequence identity with rat.
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:It is highly expressed in human lungs, heart, kidneys, liver, spleen, thymus, prostate, ovaries, small intestine, thyroid gland, lymph nodes, trachea, adrenal glands, testes, and bone marrow. Its expression level is extremely low in the brain, placenta, and skeletal muscle. It is highly expressed in fetal kidneys, liver, and lungs.
Induction:Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids -
Subunit
Homodimer. Interacts with TNFSF10 and TNFSF11
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SwissProt ID
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Synonyms
TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin
Documentation
References
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