PD-1 Antibody (YA4278)
(Synonyms: PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1)PD-1 Antibody (YA4278) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PD-1.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
PD-1 Antibody (YA4278) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PD-1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Purified recombinant fragment of human PD1 (AA: extra 21-170) expressed in HEK293 cells.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD279 (PD-1, PDCD1) is a classic immune checkpoint receptor primarily expressed on activated T cells, exhausted T cells, Tregs, and a subset of NK cells. By binding to PD-L1/PD-L2 and inhibiting TCR signaling, it suppresses T-cell proliferation and cytotoxic function; it serves as a key target in research concerning tumor immune escape, T-cell exhaustion, and immunotherapy.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Subunit
Monomer. Interacts with CD274/PDCD1L1. Interacts with FBXO38; leading to ubiquitination and degradation of PDCD1 by the proteasome
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SwissProt ID
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Synonyms
PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
Documentation
[1]. Fife BT, et al. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann N Y Acad Sci. 2011 Jan;1217:45-59. [Content Brief]
[2]. Xiao X, et al. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nat Commun. 2023 May 19;14(1):2859. [Content Brief]
[3]. Berger KN, et al. PD-1 pathway and its clinical application: A 20year journey after discovery of the complete human PD-1 gene. Gene. 2018 Jan 5;638:20-25. [Content Brief]
[4]. Topalian SL, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012 Jun 28;366(26):2443-54. [Content Brief]
[5]. Robert C, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014 Sep 20;384(9948):1109-17. [Content Brief]
[6]. Robert C, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015 Jan 22;372(4):320-30. [Content Brief]
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