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PEA3 Antibody (YA4020)(PBS only)

(Synonyms: HGK; NIK; PEA3)

PEA3 Antibody (YA4020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PEA3.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • PEA3 Antibody (YA4020)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:400 1:10000

Product Details

Description

PEA3 Antibody (YA4020) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PEA3.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 54 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 54 kDa
Immunogen

Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PEA3 transcriptional activator. May play a role in keratinocyte differentiation; (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'[1][2].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:Expressed in keratinocytes

  • Isoforms & Post-Translational Modification

    P43268 has 3 isomers: P43268-1: 53938 Da (predicted); P43268-2: 49659 Da (predicted); P43268-3: 23422 Da (predicted).
    Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2

  • SwissProt ID

    P43268

  • Gene ID
    2118 [NCBI]
  • Synonyms

    HGK; NIK; PEA3

PEA3 Antibody (YA4020)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PEA3 Antibody (YA4020)(PBS only) Product Image