PLCB2 Antibody
(Synonyms: Phosphoinositide phospholipase C-beta-2, Phospholipase C-beta-2, PLC-beta-2, PLCB2)PLCB2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PLCB2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, FC, IF-Tissue
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000: IHC-P: 1:100-500 | 1:100-500 | 1:100-500 | 1μg/Test |
Product Details
PLCB2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PLCB2.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse Predicted Reactivity: Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 27 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 27 kDa
Synthetic peptide derived from human Phospholipase C beta 2 : 401-500/1185.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PLCB2 is a The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity)[1][2].
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Isoforms & Post-Translational Modification
PLCB2 has 3 isoforms, Q00722-1: amino acid length is 1185, molecular weight is 134024 Da (predicted); Q00722-2: amino acid length is 1181, molecular weight is 133680 Da (predicted); Q00722-3: amino acid length is 1170, molecular weight is 132511 Da (predicted).
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Subunit
Interacts with RAC1.
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SwissProt ID
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Synonyms
Phosphoinositide phospholipase C-beta-2, Phospholipase C-beta-2, PLC-beta-2, PLCB2
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Research Field
Signal Transduction
Documentation
[1]. Park D, et al. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. J Biol Chem. 1992 Aug 15;267(23):16048-55. [Content Brief]
[2]. Tall E, et al. Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. Biochemistry. 1997 Jun 10;36(23):7239-48. [Content Brief]
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