PLEKHA3 Antibody (YA8462)
(Synonyms: FAPP1)PLEKHA3 Antibody (YA8462) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PLEKHA3.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
PLEKHA3 Antibody (YA8462) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PLEKHA3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 33.7 kDa
Full length human recombinant protein of human PLEKHA3 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PLEKHA3 plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration. Binds preferentially to PtdIns(4)P. Negatively regulates APOB secretion from hepatocytes[1][2][3].
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Subcellular Localization
Golgi apparatus, trans-Golgi network membrane
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
Q9HB20: 300 amino acids, molecular weight 33861 Da.
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Subunit
Interacts with GTP-bound ARF1 (PubMed:15107860, PubMed:21454700)
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SwissProt ID
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Synonyms
FAPP1
Documentation
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