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Cat. No.: HY-P87572

PLSCR3 Antibody (YA7256)

PLSCR3 Antibody (YA7256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Stock

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry
Dilution Ratio	1:500-2000	1:50-100

Description

PLSCR3 Antibody (YA7256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 32 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 32 kDa

Immunogen

A synthesized peptide derived from human PLSCR3

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

PLSCR3 catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8].
Subcellular Localization

Mitochondrion membrane,Mitochondrion inner membrane,Nucleus
Expression

Tissue_Specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver
Isoforms & Post-Translational Modification

Q9NRY6: 295 amino acids, molecular weight 31648 Da.
Subunit

Monomer (PubMed:29337693)
SwissProt ID

Q9NRY6