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POFUT2 Antibody (YA8583)(PBS only)

(Synonyms: C21orf80; FUT13)

POFUT2 Antibody (YA8583) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to POFUT2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • POFUT2 Antibody (YA8583)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100

Product Details

Description

POFUT2 Antibody (YA8583) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to POFUT2.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 49.8 kDa
Immunogen

Full length human recombinant protein of human POFUT2 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    POFUT2 catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm[1][2][3].

  • Subcellular Localization

    Endoplasmic reticulum,Golgi apparatus

  • Expression


    Tissue_Specificity: Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart

  • Isoforms & Post-Translational Modification

    Q9Y2G5 has three isomers: Q9Y2G5-3: 49976 Da (predicted); Q9Y2G5-1: 48896 Da (predicted); Q9Y2G5-2: 44083 Da (predicted).

  • SwissProt ID

    Q9Y2G5

  • Synonyms

    C21orf80; FUT13

POFUT2 Antibody (YA8583)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • POFUT2 Antibody (YA8583)(PBS only) Product Image
    1/16
  • POFUT2 Antibody (YA8583)(PBS only) Product Image