POLDIP2 Antibody (YA9760)
(Synonyms: POLDIP2, DNA Polymerase Delta Interacting Protein 2, PDIP38, Polymerase (DNA-Directed), Delta Interacting Protein 2, 38 KDa DNA Polymerase Delta Interaction Protein, Polymerase Delta-Interacting Protein 2, DKFZP586F1524, POLD4, P38, Polymerase (DNA) Delta Interacting Protein 2, Polymerase Delta Interacting Protein 38)POLDIP2 Antibody (YA9760) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to POLDIP2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, ICC/IF
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Reactivity :
Human, mouse, rat
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:200-2000 | 1:100-1000 |
Product Details
POLDIP2 Antibody (YA9760) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to POLDIP2.
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Host Rabbit
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Species ReactivityHuman, mouse, rat
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Observed Molecular WeightObserved band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa,
A synthesized peptide derived from human POLDIP2
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
POLDIP2 is involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1)[1][2].
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Subcellular Localization
Mitochondrion matrix; Nucleus
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Isoforms & Post-Translational Modification
POLDIP2 has an amino acid length of 368, molecular weight is 42033 Da.
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Subunit
Interacts with PCNA and POLD2.
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SwissProt ID
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Synonyms
POLDIP2, DNA Polymerase Delta Interacting Protein 2, PDIP38, Polymerase (DNA-Directed), Delta Interacting Protein 2, 38 KDa DNA Polymerase Delta Interaction Protein, Polymerase Delta-Interacting Protein 2, DKFZP586F1524, POLD4, P38, Polymerase (DNA) Delta Interacting Protein 2, Polymerase Delta Interacting Protein 38
Documentation
References
[1]. Maga G, et al. DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18850-5. [Content Brief]
[2]. Guilliam TA, et al. PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Res. 2016 Apr 20;44(7):3317-29. [Content Brief]
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