RAMP2 Antibody (YA8345)(PBS only)

Cat. No.: HY-P88661A: Data Sheet User Guide for Antibodies
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RAMP2 Antibody (YA8345) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAMP2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RAMP2 Antibody (YA8345) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAMP2.

Host

Mouse

Molecular Weight

Predicted band size: 15.8 kDa

Species Reactivity

Human

SwissProt ID

O60895

Immunogen

Full length human recombinat protein of human RAMP2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:22102369, PubMed:32296767, PubMed:9620797). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC (PubMed:35324283). Together with CALCR, also act as a receptor complex for amylin/IAPP (PubMed:35324283)

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Strongly expressed in lung, breast, immune system and fetal tissues

Isoforms & Post-Translational Modification：O60895 has two isomers: O60895-1: 19608 Da (predicted); O60895-2: 20063 Da (predicted).

Subunit：Heterodimer of CALCRL and RAMP2; the interaction forms the receptor complex for adrenomedullin/ADM (PubMed:30115739)

Synonyms

Receptor activity-modifying protein 2, Calcitonin-receptor-like receptor activity-modifying protein 2, CRLR activity-modifying protein 2, RAMP2

Documentation

User Guide for Antibodies (1077 KB)