SLC22A12 Antibody (YA4439)(PBS only)
(Synonyms: RST; OAT4L; URAT1)SLC22A12 Antibody (YA4439) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A12.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
SLC22A12 Antibody (YA4439) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A12.
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Host Mouse
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 60 kDa
Purified recombinant fragment of human SLC22A12 (AA: 30-145) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC22A12 is an Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange witH2O2ganic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent[1][2][3][4][5].
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Subcellular Localization
Apical cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Detected in kidney (at protein level) . Detected in human kidney. Detected in epithelial cells of proximal tubules in renal cortex -
Isoforms & Post-Translational Modification
Q96S37 has 4 isomers: Q96S37-1: 59630 Da (predicted); Q96S37-2: 47648 Da (predicted); Q96S37-3: 35570 Da (predicted); Q96S37-4: 56094 Da (predicted).
N-glycosylated -
Subunit
Interacts with PDZK1
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SwissProt ID
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Synonyms
RST; OAT4L; URAT1
Documentation
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