SLC22A12 Antibody (YA4439)(PBS only)

Cat. No.: HY-P84742A: Data Sheet User Guide for Antibodies
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SLC22A12 Antibody (YA4439) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A12.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

SLC22A12 Antibody (YA4439) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A12.

Host

Mouse

분자량

Predicted band size: 60 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q96S37

Gene ID

116085 [NCBI]

Immunogen

Purified recombinant fragment of human SLC22A12 (AA: 30-145) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange witH2O2ganic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910)

Subcellular Localization：Apical cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Detected in kidney (at protein level) . Detected in human kidney. Detected in epithelial cells of proximal tubules in renal cortex

Isoforms & Post-Translational Modification：Q96S37 has 4 isomers: Q96S37-1: 59630 Da (predicted); Q96S37-2: 47648 Da (predicted); Q96S37-3: 35570 Da (predicted); Q96S37-4: 56094 Da (predicted).
N-glycosylated

Subunit：Interacts with PDZK1

Synonyms

RST; OAT4L; URAT1

각종 서류

User Guide for Antibodies (1077 KB)