SPATA5L1 Antibody (YA7052)
(Synonyms: FLJ12286 antibody; MGC5347 antibody; SPA5L_HUMAN antibody; SPATA5L1 antibody; Spermatogenesis-associated protein 5-like protein 1 antibody)SPATA5L1 Antibody (YA7052) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SPATA5L1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Rat
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:200 | 1:50-1:200 | 1:50-1:100 |
Product Details
SPATA5L1 Antibody (YA7052) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SPATA5L1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 81 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 81 kDa
Recombinant protein within Human SPATA5L1 aa 379-580 / 753.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SPATA5L1 is an ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles[1][2].
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Subcellular Localization
Cytoplasm,Cytoplasm, cytoskeleton, spindle,Nucleus
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Expression
Tissue_Specificity: Expressed in both neurons and glia during embryonic and adult stages of brain development -
Isoforms & Post-Translational Modification
Q9BVQ7 has three isomers: Q9BVQ7-1: 80710 Da (predicted); Q9BVQ7-2: 66111 Da (predicted); Q9BVQ7-3: 41138 Da (predicted).
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Subunit
Part of the 55LCC heterohexameric ATPase complex composed at least of AIRIM, AFG2A, AFG2B and CINP (PubMed:35354024, PubMed:38554706)
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SwissProt ID
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Synonyms
FLJ12286 antibody; MGC5347 antibody; SPA5L_HUMAN antibody; SPATA5L1 antibody; Spermatogenesis-associated protein 5-like protein 1 antibody
Documentation
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