SRP54 Antibody (YA2137)
(Synonyms: SRP54)SRP54 Antibody (YA2137) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SRP54.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP, FC
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Reactivity :
Mouse, Rat, Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50 | 1:50-1:100 |
Product Details
SRP54 Antibody (YA2137) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SRP54.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityMouse, Rat, Human
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Observed Molecular WeightObserved band size: 56 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 56 kDa
Entrez Gene: 6729 Human ; 24067 Mouse ; 116650 Rat
SwissProt: P61011 Human ; P14576 Mouse ; Q6AYB5 Rat
OMIM: 618752 Human
A synthesized peptide derived from human SRP54 aa450-504/504.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SRP54 component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development[1][2][3].
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Subcellular Localization
Nucleus speckle; Cytoplasm; Endoplasmic reticulum
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Isoforms & Post-Translational Modification
P61011 has 2 isomers: P61011-1: 55705 Da (predicted); P61011-2: 50369 Da (predicted).
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Subunit
Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:12244299). Interacts with RNPS1 (PubMed:14729963). Interacts with the SRP receptor subunit SRPRA (PubMed:34020957)
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SwissProt ID
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Synonyms
SRP54
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Research Field
Signal Transduction
Documentation
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