TBC1D21 Antibody (YA8548)
(Synonyms: MgcRabGAP)
Based on 1 Customer Validation
TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:150-500 | 1:100 |
Product Details
TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 39 kDa
Full length human recombinant protein of human TBC1D21 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TBC1D21 acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity[1][2][3].
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Subcellular Localization
Cytoplasmic vesicle, secretory vesicle, acrosome,Cytoplasm, cytoskeleton
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Expression
Tissue_Specificity: Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain -
Isoforms & Post-Translational Modification
Q8IYX1 has two isomers: Q8IYX1-1: 39221 Da (predicted); Q8IYX1-2: 34961 Da (predicted).
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Subunit
Interacts with ACTB (By similarity)
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SwissProt ID
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Synonyms
MgcRabGAP
Documentation
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