TBC1D21 Antibody (YA8548)

Cat. No.: HY-P88864: Data Sheet User Guide for Antibodies
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TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TBC1D21 Antibody (YA8548) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TBC1D21.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 39 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8IYX1

Immunogen

Full length human recombinant protein of human TBC1D21 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034, PubMed:28067790). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978)

Subcellular Localization：Cytoplasmic vesicle, secretory vesicle, acrosome,Cytoplasm, cytoskeleton

Expression：
Tissue_Specificity: Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain

Isoforms & Post-Translational Modification：Q8IYX1 has two isomers: Q8IYX1-1: 39221 Da (predicted); Q8IYX1-2: 34961 Da (predicted).

Subunit：Interacts with ACTB (By similarity)

Synonyms

MgcRabGAP

Documentation

User Guide for Antibodies (1077 KB)